ALT is classically used as a marker of which type of liver injury?

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Multiple Choice

ALT is classically used as a marker of which type of liver injury?

Explanation:
ALT, or alanine aminotransferase, is an enzyme concentrated in liver cells. When hepatocytes are damaged, ALT leaks into the bloodstream, causing a rise in serum ALT. This makes ALT a classic marker of hepatocellular injury, such as from viral hepatitis or toxin-induced liver damage. In contrast, cholestasis (biliary obstruction) more commonly elevates alkaline phosphatase and gamma-glutamyl transferase due to impaired bile flow, not primary hepatocyte death. Renal or pancreatic injuries do not principally drive ALT elevations. Thus, ALT specifically reflects hepatocellular injury.

ALT, or alanine aminotransferase, is an enzyme concentrated in liver cells. When hepatocytes are damaged, ALT leaks into the bloodstream, causing a rise in serum ALT. This makes ALT a classic marker of hepatocellular injury, such as from viral hepatitis or toxin-induced liver damage. In contrast, cholestasis (biliary obstruction) more commonly elevates alkaline phosphatase and gamma-glutamyl transferase due to impaired bile flow, not primary hepatocyte death. Renal or pancreatic injuries do not principally drive ALT elevations. Thus, ALT specifically reflects hepatocellular injury.

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