Mutation ΔF508 in CFTR gene leads to defective chloride transport. What organ system is most impacted?

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Multiple Choice

Mutation ΔF508 in CFTR gene leads to defective chloride transport. What organ system is most impacted?

Explanation:
Mutation ΔF508 in CFTR causes defective chloride transport across epithelial surfaces. Normally, CFTR channels move chloride out of cells and drive water into mucosal secretions; when this channel is defective, secretions become thick and dehydrated. In the lungs, thick mucus plugs airways, leading to recurrent infections and bronchiectasis. In the pancreas, mucus plugs pancreatic ducts, causing exocrine insufficiency and malabsorption. Because these secretions impact both the airways and the pancreatic ducts, this pattern most strongly affects the lungs (airways) and pancreas.

Mutation ΔF508 in CFTR causes defective chloride transport across epithelial surfaces. Normally, CFTR channels move chloride out of cells and drive water into mucosal secretions; when this channel is defective, secretions become thick and dehydrated. In the lungs, thick mucus plugs airways, leading to recurrent infections and bronchiectasis. In the pancreas, mucus plugs pancreatic ducts, causing exocrine insufficiency and malabsorption. Because these secretions impact both the airways and the pancreatic ducts, this pattern most strongly affects the lungs (airways) and pancreas.

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