The presence of Reed-Sternberg cells on biopsy is characteristic of which disease?

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Multiple Choice

The presence of Reed-Sternberg cells on biopsy is characteristic of which disease?

Explanation:
Reed-Sternberg cells are large malignant B cells with a distinctive owl’s-eye appearance, usually found in Hodgkin lymphoma. Their presence on biopsy, often within a mixed inflammatory background, is the hallmark of this disease. These cells characteristically express CD30 and CD15, and are typically negative for CD45, with some cases showing EBV association. This pattern distinguishes Hodgkin lymphoma from other lymphomas, such as Burkitt lymphoma or diffuse large B-cell lymphoma, which do not rely on RS cells for diagnosis and show different cellular morphology and immunophenotypes.

Reed-Sternberg cells are large malignant B cells with a distinctive owl’s-eye appearance, usually found in Hodgkin lymphoma. Their presence on biopsy, often within a mixed inflammatory background, is the hallmark of this disease. These cells characteristically express CD30 and CD15, and are typically negative for CD45, with some cases showing EBV association. This pattern distinguishes Hodgkin lymphoma from other lymphomas, such as Burkitt lymphoma or diffuse large B-cell lymphoma, which do not rely on RS cells for diagnosis and show different cellular morphology and immunophenotypes.

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