What lab finding is characteristic of Dubin-Johnson syndrome?

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Multiple Choice

What lab finding is characteristic of Dubin-Johnson syndrome?

Explanation:
Dubin-Johnson syndrome is defined by a defect in the canalicular transporter that exports conjugated bilirubin into bile. Because this excretion step is impaired, conjugated bilirubin backs up into the bloodstream, producing a direct (conjugated) hyperbilirubinemia while liver enzymes like ALT and AST remain normal, reflecting preserved hepatocellular integrity. This distinguishes it from conditions with unconjugated hyperbilirubinemia (Gilbert or Crigler-Najjar) or from hepatocellular injury (where transaminases are elevated).

Dubin-Johnson syndrome is defined by a defect in the canalicular transporter that exports conjugated bilirubin into bile. Because this excretion step is impaired, conjugated bilirubin backs up into the bloodstream, producing a direct (conjugated) hyperbilirubinemia while liver enzymes like ALT and AST remain normal, reflecting preserved hepatocellular integrity. This distinguishes it from conditions with unconjugated hyperbilirubinemia (Gilbert or Crigler-Najjar) or from hepatocellular injury (where transaminases are elevated).

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