Which lung cancer is most associated with PTHrP-mediated hypercalcemia?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the NBME Form 11 Test with targeted flashcards and multiple-choice questions. Each question includes hints and explanations to aid learning. Boost your readiness for exam day!

Multiple Choice

Which lung cancer is most associated with PTHrP-mediated hypercalcemia?

Explanation:
Hypercalcemia from a tumor can come from PTH-related peptide (PTHrP) acting like PTH, driving bone resorption and increasing renal calcium reabsorption. This raises calcium while the body's own PTH stays low due to negative feedback. In lung cancers, the classic source of PTHrP is squamous cell carcinoma, which often secretes PTHrP and causes humoral hypercalcemia. Small cell carcinoma tends to produce ACTH or ADH rather than PTHrP, and osteosarcoma or renal cell carcinoma cause hypercalcemia mainly through other mechanisms not tied to PTHrP in the lung. So the best association is squamous cell carcinoma of the lung.

Hypercalcemia from a tumor can come from PTH-related peptide (PTHrP) acting like PTH, driving bone resorption and increasing renal calcium reabsorption. This raises calcium while the body's own PTH stays low due to negative feedback. In lung cancers, the classic source of PTHrP is squamous cell carcinoma, which often secretes PTHrP and causes humoral hypercalcemia. Small cell carcinoma tends to produce ACTH or ADH rather than PTHrP, and osteosarcoma or renal cell carcinoma cause hypercalcemia mainly through other mechanisms not tied to PTHrP in the lung. So the best association is squamous cell carcinoma of the lung.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy